A POLYNUCLEOTIDE COENZYME OF OXIDATIVE PHOSPHORYLATION II
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چکیده
منابع مشابه
A requirement for coenzyme A in oxidative phosphorylation.
Experiments have shown that oxidative phosphorylation by aged, or otherwise damaged, mitochondria may be restored by additions of ATP and DPN (l), by combinations of ATP, DPN and Mn++ (2) or by bovine serum albumin (3). In the latter instance albumin apparently acts by binding an inhibitory protein, mitochrome, which is released by the mitochondria upon aging. More recently Cooper and Lehninger...
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Introduction Thyroid hormones (TI Is) affect cellular metabolism via two different pathways. The first one is the socalled nuclear, long-term effect: there the TI I binds to a nuclear receptor and regulates the transcription o f multiple cellular proteins f 11. The other pathway, the short-term extranuclear pathway, is less w d l defined and could in principle be similar to other short-term sig...
متن کاملUncouplers of oxidative phosphorylation.
Uncouplers of oxidative phosphorylation in mitochondria inhibit the coupling between the electron transport and phosphorylation reactions and thus inhibit ATP synthesis without affecting the respiratory chain and ATP synthase (H(+)-ATPase). Miscellaneous compounds are known to be uncouplers, but weakly acidic uncouplers are representative because they show very potent activities. The most poten...
متن کاملUncouplers of Oxidative Phosphorylation
was proportional to the acidity of the imidazole -NH group. Tetrachloro-2trifluoromethylbenzimidazole was the most active (50% uncoupling of oxidative phosphorylation at 7-9 x 10-8M, pK5.04). Nitro-substituted analogues were less active than predicted from pK considerations or from partition-coefficient measurements. 3. Introduction of an -NH2 or -CO2H substituent caused a loss of uncoupling ac...
متن کاملThe enzymatic phosphorylation of ribonucleic acid and deoxyribonucleic acid. II. Further properties of the 5'-hydroxyl polynucleotide kinase.
The specificity of the enzyme purified from TZ-infected Escherichia coli which catalyzes the phosphorylation of 5’hydroxyl ends of ribonucleic acid and deoxyribonucleic acid has been examined. The enzyme also catalyzes the phosphorylation of 5’-hydroxyl groups of polynucleotides as well as 3’-mononucleotides. There is no detectable phosphorylation of nucleosides and adenosine 2’-phosphate is vi...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1957
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)70590-5